After a crazy one-night bender, best buds Jesse (Ashton Kutcher) and Chester (Seann William Scott) find that they are being chased by an obsessive group of paranoid nerds, a trans-sexual stripper and some exceptionally sexy space aliens. They have a refrigerador full of pudding they can't account for. They speak Chinese. Their girlfriends are leaving them. They have new tattoos. And to top it all off, they seem to have misplaced their car. Join this dim-witted duo on their hilarious journey of mischief and mayhem, to figure out exactly how much they drank last night, and more importantly, where on earth their car is.